Neisseria meningitidis Urethritis Outbreak Isolates Express a Novel Factor H Binding Protein Variant That Is a Potential Target of Group B-Directed Meningococcal (MenB) Vaccines-Reference-Cited by-同舟云学术

Neisseria meningitidis Urethritis Outbreak Isolates Express a Novel Factor H Binding Protein Variant That Is a Potential Target of Group B-Directed Meningococcal (MenB) Vaccines

Published:2020-11-16 Issue:12 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Tzeng Yih-Ling¹^ORCID,Giuntini Serena²,Berman Zachary¹,Sannigrahi Soma¹,Granoff Dan M.³,Stephens David S.¹⁴

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

2. OMVax, Inc., San Francisco, California, USA

3. Center for Immunobiology and Vaccine Development, University of California San Francisco Benioff Children’s Hospital Oakland, Oakland, California, USA

4. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

Abstract

Factor H binding protein (FHbp) is an important Neisseria meningitidis virulence factor that binds a negative regulator of the alternative complement pathway, human factor H (FH). Binding of FH increases meningococcal resistance to complement-mediated killing. FHbp also is reported to prevent interaction of the antimicrobial peptide (AMP) LL-37 with the meningococcal surface and meningococcal killing. FHbp is a target of two licensed group B-directed meningococcal (MenB) vaccines.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00462-20

Reference67 articles.

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