Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli-Reference-Cited by-同舟云学术

Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli

Published:2019-11 Issue:11 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Maciel Milton¹²³,Bauer David⁴,Baudier Robin L.⁴,Bitoun Jacob⁴^ORCID,Clements John D.⁴,Poole Steven T.¹,Smith Mark A.⁵,Kaminski Robert W.⁵^ORCID,Savarino Stephen J.³,Norton Elizabeth B.⁴

Affiliation:

1. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

2. Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

3. Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA

4. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA

5. Subunit Enteric Vaccines and Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

Abstract

Enterotoxigenic Escherichia coli (ETEC) is a major cause of infectious diarrhea in children, travelers, and deployed military personnel. As such, development of a vaccine would be advantageous for public health. One strategy is to use subunits of colonization factors combined with antigen/adjuvant toxoids as an ETEC vaccine.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00460-19

Reference62 articles.

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3. Travelers' Diarrhea: An Update on the Incidence, Etiology, and Risk in Military Deployments and Similar Travel Populations