Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion

Author:

Ahearn C. P.12,Kirkham C.23,Chaves L. D.4,Kong Y.56,Pettigrew M. M.7,Murphy T. F.123

Affiliation:

1. Department of Microbiology and Immunology, University at Buffalo, the State University of New York, Buffalo, New York, USA

2. Clinical and Translational Research Center, University at Buffalo, the State University of New York, Buffalo, New York, USA

3. Division of Infectious Disease, Department of Medicine, University at Buffalo, the State University of New York, Buffalo, New York, USA

4. Division of Nephrology, Department of Medicine, University at Buffalo, the State University of New York, Buffalo, New York, USA

5. Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, USA

6. W. M. Keck Foundation Biotechnology Resource Laboratory, Yale School of Medicine, Yale University, New Haven, Connecticut, USA

7. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, USA

Abstract

Nontypeable Haemophilus influenzae (NTHi) is the primary cause of bacterially induced acute exacerbations of chronic obstructive pulmonary disease (COPD). NTHi adheres to and invades host respiratory epithelial cells as a means to persist in the lower airways of adults with COPD. Therefore, we mined the genomes of NTHi strains isolated from the airways of adults with COPD to identify novel proteins to investigate their role in adherence and invasion of human respiratory epithelial cells.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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