Prophylactic Inhibition of Colonization by Streptococcus pneumoniae with the Secondary Bile Acid Metabolite Deoxycholic Acid-Reference-Cited by-同舟云学术

Prophylactic Inhibition of Colonization by Streptococcus pneumoniae with the Secondary Bile Acid Metabolite Deoxycholic Acid

Published:2021-11-16 Issue:12 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Vidal Jorge E.¹^ORCID,Wier Meagan N.¹,A. Angulo-Zamudio Uriel²,McDevitt Erin¹,Jop Vidal Ana G.¹,Alibayov Babek¹,Scasny Anna¹,Wong Sandy M.¹,Akerley Brian J.¹^ORCID,McDaniel Larry S.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, USA

2. University of Sinaloa School of Medicine, CIASaP, Culiacan Sinaloa, Mexico

Abstract

Streptococcus pneumoniae colonizes the nasopharynx of children and the elderly but also kills millions worldwide yearly. The secondary bile acid metabolite deoxycholic acid (DoC) affects the viability of human pathogens but also plays multiple roles in host physiology.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of State

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00463-21

Reference92 articles.

1. Influence of bacterial interactions on pneumococcal colonization of the nasopharynx

2. The fundamental link between pneumococcal carriage and disease