Highly Purified Vitamin B2 Presents a Promising Therapeutic Strategy for Sepsis and Septic Shock-Reference-Cited by-同舟云学术

Highly Purified Vitamin B2 Presents a Promising Therapeutic Strategy for Sepsis and Septic Shock

Published:2004-03 Issue:3 Volume:72 Page:1820-1823
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Toyosawa Toshio¹,Suzuki Mamoru¹,Kodama Kohtarou¹,Araki Seiichi¹

Affiliation:

1. Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki 300-2635, Japan

Abstract

ABSTRACT Highly purified vitamin B2 (riboflavin 5′-sodium phosphate; purity > 97%) treatment by intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed therapeutic effects in mice not only in cases of endotoxin- and exotoxin-induced shock but also in cases of gram-negative and gram-positive bacterial infection even after the toxemia had already begun.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.3.1820-1823.2004

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