Affiliation:
1. Squibb Institute for Medical Research, New Brunswick, New Jersey
Abstract
Meyers, Edward
(Squibb Institute for Medical Research, New Brunswick, N.J.)
and Dorothy A. Smith
. Microbiological degradation of tetracyclines. J. Bacteriol.
84:
797–802. 1962—The degradation of tetracyclines by an ascomycete,
Xylaria digitata
, was demonstrated. Washedcell suspensions were capable of degrading tetracycline, 5-hydroxytetracycline, 7-chlortetracycline, 7-chlor-6-demethyltetracycline, 2-acetyl-2-decarboxamido-5-hydroxytetracycline, and 12-α-deoxytetracycline. The influence of environmental conditions upon the degradation of tetracycline was investigated. A nonantibacterial, nonfluorescent product was located from the degradation of
14
C 5-hydroxytetracycline. Evidence indicated that neither the A nor D ring of 5-hydroxytetracycline is attacked. Acetone powders, lyophilized powders, and cell-free extracts exhibited a relatively limited substrate specificity compared to the washed cells.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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