Effect of monophosphoryl lipid A on host resistance to bacterial infection

Author:

Chase J J,Kubey W,Dulek M H,Holmes C J,Salit M G,Pearson F C,Ribi E

Abstract

The ability of monophosphoryl lipid A (MPLA) to enhance nonspecific host resistance to bacterial infections was studied. Mice were treated with MPLA prior to intraperitoneal challenge with Escherichia coli or Staphylococcus epidermidis. Animals received additional MPLA for 2 days postinfection, and survival rates were determined. Ten micrograms of MPLA per mouse significantly improved the survival of animals infected with either bacterial species. Dose-response studies showed significant MPLA-induced protection at doses of 6 micrograms/kg against E. coli challenge and 60 micrograms/kg against S. epidermidis challenge.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference7 articles.

1. Cleeland R. and E. Grunberg. 1980. Laboratory evaluation of new antibiotics in vitro and in experimental animal infections p. 506-548. In V. Lorian (ed.) Antibiotics in laboratory medicine. The Williams & Wilkins Co. Baltimore.

2. Jones R. N. A. L. Barry T. L. Gavan and J. A. Washington II. 1985. Susceptibility tests: microdilution and macrodilution broth procedures p. 972-977. In E. H. Lennette A. Balows W. J. Hausler Jr. and H. J. Shadomy (ed.) Manual of clinical microbiology 4th ed. American Society for Microbiology Washington D.C.

3. Ribi E. 1984. Advances in carriers and adjuvants for veterinary biologics. Iowa State University Press Ames.

4. Beneficial modification of the endotoxin molecule;Ribi E.;J. Biol. Response Modif.,1984

5. Preparation and antitumor activity of nontoxic lipid A;Ribi E.;Cancer Immunol. Immunother.,1982

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3