Affiliation:
1. Department of Chemical Engineering, Stanford University, Stanford, California 94305
Abstract
ABSTRACT
We report an altered pattern of genetic instability for
Streptomyces coelicolor
when the bacterium harbored a foreign transposon, Tn
4560
. Deletions, amplifications, and circularizations of the linear 8.7-Mb chromosome occurred more frequently at sites adjacent to native insertion elements, notably IS
1649
. In contrast, deletions, amplifications, and circularizations of a wild-type strain happened at heterogeneous sites within the chromosome. In 50 strains examined, structural changes removed or duplicated hundreds of contiguous
S. coelicolor
genes, altering up to 33% of the chromosome.
S. coelicolor
shows a bias toward one type of genetic instability during this particular assault from the environment, the invasion of foreign DNA.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
13 articles.
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