Affiliation:
1. National Veterinary Laboratory, Copenhagen, Denmark.
Abstract
This study investigated the functional capabilities of neutrophils against different Staphylococcus aureus genotypes isolated from cows with mastitis. Six strains of S. aureus were chosen for use in the study, two with a common genotype, two with an intermediate genotype, and two with a rare genotype. The interaction between bacteria and neutrophils was measured by phagocytosis and bactericidal effect. The average percent killing of bacteria was lowest (40.0%) with strains belonging to the most common genotype, medium (50%) with strains belonging to the intermediate type, and highest (64.2%) with strains belonging to the rare type (P < or = 0.001). Statistically significant differences (P < or = 0.001) in the numbers of phagocytized bacteria were also found between the most prevalent type (6.27 bacteria per cell) and the other two types (intermediate type, 9.26/cell; rare type, 10.5/cell). These findings suggest that one of the reasons for the variation in prevalence of different genotypes of S. aureus in the mammary gland is due to the superior ability of some types to resist phagocytosis and/or killing by bovine neutrophils.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference28 articles.
1. Aarestrup F. M. C. A. Dangler and L. M. Sordillo. Prevalence of coagulase gene polymorphisms of Staphylococcus aureus causing bovine mastitis. Can. J. Vet. Res. in press.
2. Mechanisms of staphylococcal virulence in relation to bovine mastitis;Anderson J. C.;Br. Vet. J.,1976
3. Blosser T. H. 1979. Economic losses from and the National Research Program on mastitis in the United States. J. Dairy Sci. 5682 NOTES
4. The role of coagulase in the defense of Staphylococcus aureus against phagocytosis;Cawdery M.;Br. J. Exp. Pathol.,1969
5. Collaborative investigation of phages for typing bovine staphylococci;Davidson I. A.;Bull. W. H. O.,1972
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