Endogenous C-Type Viruses of BALB/c Cells: Frequencies of Spontaneous and Chemical Induction

Author:

Aaronson Stuart A.1,Dunn Claire Y.2

Affiliation:

1. Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

2. Hazleton Laboratories, Inc., Vienna, Virginia 22180

Abstract

A sensitive biological assay has been developed for studying the frequency of virus induction from mouse cells containing poorly infectious endogenous C-type viruses. A low spontaneous frequency of virus activation of one but not a second endogenous virus of BALB/c cells has been demonstrated. The resistance of BALB/c cells to superinfection by the more inducible virus appears to be absolute, whereas resistance to the other virus is only relative. Thus, the evidence indicates that the BALB/c cell exerts differential effects at two levels of regulation on the expression of its biologically distinguishable endogenous C-type viruses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference20 articles.

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3. Murine sarcoma transformation of BALB/3T3 cells: lack of dependence on murine leukemia virus;Aaronson S. A.;Proc. Nat. Acad. Sci. U.S.A.,1970

4. Nonproducer clones of murine sarcoma virus transformed BALB/3T3 cells;Aaronson S. A.;Virology,1970

5. Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells;Aaronson S. A.;Proc. Nat. Acad. Sci. U.S.A.,1973

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