Antibiotic-Resistant Cell-Detaching Escherichia coli Strains from Nigerian Children-Reference-Cited by-同舟云学术

Antibiotic-Resistant Cell-Detaching Escherichia coli Strains from Nigerian Children

Published:2002-01 Issue:1 Volume:40 Page:301-305
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Okeke Iruka N.¹²,Steinrück Hartmut³,Kanack Kristen J.¹,Elliott Simon J.¹,Sundström Lars⁴,Kaper James B.¹,Lamikanra Adebayo²

Affiliation:

1. Department of Microbiology and Immunology and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201

2. Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria

3. Federal Institute for Health Protection of Consumers and Veterinary Medicine, D-12277 Berlin, Germany

4. Division of Microbiology, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala S-751 23, Sweden

Abstract

ABSTRACT The properties of 23 cell-detaching Escherichia coli strains that were isolated from stool specimens in Nigeria are described. Common properties of the strains included the presence of genes encoding α-hemolysin (100%), pyelonephritis-associated pili (100%), and cytotoxic necrotizing factor 1 (70%) as well as lactose negativity (70%) and multiple antibiotic resistance (74%). Antibiotic resistance was shown in most cases to be transferable and associated with the presence of class 1 integrons. Phenotypic properties and pulsed-field gel electrophoresis analysis demonstrated that the majority of the strains, particularly multiply resistant, lactose-negative O4:H40 strains, were closely related. Multiply-resistant cell-detaching E. coli strains may represent an important reservoir for antibiotic resistance genes.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.40.1.301-305.2002

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