Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae-Reference-Cited by-同舟云学术

Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae

Published:2001-09 Issue:9 Volume:45 Page:2631-2634
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bast Darrin J.¹²,de Azavedo Joyce C. S.¹²,Tam Tiffany Y.¹,Kilburn Laurie¹,Duncan Carla¹,Mandell Lionel A.³,Davidson Ross J.⁴,Low Donald E.¹²

Affiliation:

1. Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital,1 and

2. Department of Laboratory Medicine and Pathobiology, University of Toronto,2 Toronto,

3. Division of Infectious Diseases, McMaster University, and Henderson Site, Hamilton Health Sciences Corporation, Hamilton,3 and

4. Department of Microbiology, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax,4Canada

Abstract

ABSTRACT Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC , parE , and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.9.2631-2634.2001

Reference27 articles.

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