Risk Factors for Emergence of Resistance to Broad-Spectrum Cephalosporins among Enterobacter spp-Reference-Cited by-同舟云学术

Risk Factors for Emergence of Resistance to Broad-Spectrum Cephalosporins among Enterobacter spp

Published:2001-09 Issue:9 Volume:45 Page:2628-2630
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kaye Keith S.¹,Cosgrove Sara¹,Harris Anthony²,Eliopoulos George M.¹,Carmeli Yehuda¹

Affiliation:

1. Division of Infectious Diseases and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts,1and the

2. Division of Healthcare Outcomes, Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland2

Abstract

ABSTRACT Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were trends toward decreased risk for resistance among patients receiving broad-spectrum cephalosporins and either aminoglycosides or imipenem. Of the patients receiving broad-spectrum cephalosporins, 19% developed resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.9.2628-2630.2001

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