Klebsiella pneumoniae Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation-Reference-Cited by-同舟云学术

Klebsiella pneumoniae Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation

Published:2019-12-17 Issue:1 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Karadottir Harpa¹,Coorens Maarten¹,Liu Zhihai²³,Wang Yang³,Agerberth Birgitta¹,Giske Christian G.¹⁴,Bergman Peter¹⁵

Affiliation:

1. Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden

2. Agricultural Bio-pharmaceutical Laboratory, College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, China

3. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China

4. Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden

5. Infectious Disease Clinic, Immunodeficiency Unit, Karolinska University Hospital, Stockholm, Sweden

Abstract

Antibiotic-resistant Klebsiella pneumoniae isolates constitute a great clinical challenge. One important resistance mechanism in K. pneumoniae is the metallo-β-lactamases (MBLs), which require zinc for their function. Thus, zinc chelation could be a strategy to resensitize K. pneumoniae to β-lactams. However, the potential role for endogenous zinc chelators for this purpose remains to be explored.

Funder

Vetenskapsrådet

Torsten Söderbergs Stiftelse

Karolinska Institutet

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00756-19

Reference26 articles.

1. Progress and Challenges in Implementing the Research on ESKAPE Pathogens