Dendritic Cells Targeting Lactobacillus plantarum Strain NC8 with a Surface-Displayed Single-Chain Variable Fragment of CD11c Induce an Antigen-Specific Protective Cellular Immune Response-Reference-Cited by-同舟云学术

Dendritic Cells Targeting Lactobacillus plantarum Strain NC8 with a Surface-Displayed Single-Chain Variable Fragment of CD11c Induce an Antigen-Specific Protective Cellular Immune Response

Published:2020-01-22 Issue:2 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Liu Jing¹²,Yang Guilian¹,Huang Haibin¹,Shi Chunwei¹,Gao Xing¹,Yang Wentao¹,Zhang Zan¹,Liu Yang¹,Xu Ke¹,Wang Jianzhong¹,Kang Yuanhuan¹,Jiang Yanlong¹,Wang Chunfeng¹

Affiliation:

1. College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Laboratory of Animal Production and Product Quality Safety of Ministry of Education, Jilin Agricultural University, Changchun, China

2. College of Animal Science, Yangtze University, Jingzhou, China

Abstract

Influenza A virus (H1N1) is an acute, highly contagious respiratory virus. The use of lactic acid bacteria (LAB) to deliver mucosal vaccines against influenza virus infection is a research hot spot. In this study, two recombinant Lactobacillus plantarum strains expressing hemagglutinin (HA) alone or coexpressing aCD11c-HA to target HA protein to dendritic cells (DCs) by fusion to an anti-CD11c single-chain antibody (aCD11c) were constructed.

Funder

National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00759-19

Reference39 articles.

1. Molecular epidemiology of the hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran

2. Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum

3. Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings