Affiliation:
1. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Abstract
In the acidic lysosome-like digestive vacuole,
Plasmodium
parasites crystallize heme from hemoglobin into hemozoin, or malaria pigment. Upon release of progeny merozoites, the residual hemozoin is phagocytized by macrophages principally in the liver and spleen where the heme crystals can persist for months to years, as heme oxygenase does not readily degrade the crystal.
Funder
Bloomberg Family Foundation
JHU | JHSPH | Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
3 articles.
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