Loss of Neutrophil Homing to the Periodontal Tissues Modulates the Composition and Disease Potential of the Oral Microbiota-Reference-Cited by-同舟云学术

Loss of Neutrophil Homing to the Periodontal Tissues Modulates the Composition and Disease Potential of the Oral Microbiota

Published:2021-11-16 Issue:12 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hashim A.¹,Alsam A.²,Payne M. A.²,Aduse-Opoku J.³,Curtis M. A.³,Joseph S.³^ORCID

Affiliation:

1. Department of Biomedical Sciences, College of Dentistry, King Faisal University, Al-Ahsa, Saudi Arabia

2. Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

3. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, United Kingdom

Abstract

Periodontal disease is considered to arise from an imbalance in the interplay between the host and its commensal microbiota, characterized by inflammation, destructive periodontal bone loss, and a dysbiotic oral microbial community. The neutrophil is a key component of defense of the periodontium: defects in their number or efficacy of function predisposes individuals to development of periodontal disease.

Funder

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00309-21

Reference35 articles.

1. Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

2. Bacteriology of severe periodontitis in young adult humans

3. Periodontitis: a polymicrobial disruption of host homeostasis