EspH Suppresses Erk by Spatial Segregation from CD81 Tetraspanin Microdomains-Reference-Cited by-同舟云学术

EspH Suppresses Erk by Spatial Segregation from CD81 Tetraspanin Microdomains

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ramachandran Rachana Pattani¹,Vences-Catalán Felipe²,Wiseman Dan¹,Zlotkin-Rivkin Efrat¹,Shteyer Eyal³,Melamed-Book Naomi⁴,Rosenshine Ilan⁵,Levy Shoshana²,Aroeti Benjamin¹

Affiliation:

1. Department of Cell and Developmental Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

2. Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

3. Department of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel

4. Bioimaging Unit, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

5. Department of Microbiology and Molecular Genetics, IMRIC, Hadassah-Hebrew University Medical School, Hebrew University, Jerusalem, Israel

Abstract

Enteropathogenic Escherichia coli (EPEC) belongs to a group of enteric human pathogens known as attaching-and-effacing (A/E) pathogens, which utilize a type III secretion system (T3SS) to translocate a battery of effector proteins from their own cytoplasm into host intestinal epithelial cells. Here we identified EspH to be an effector that prompts the recruitment of the tetraspanin CD81 to infection sites.

Funder

Israel Science Foundation

United States - Israel Binational Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00303-18

Reference69 articles.

1. LEEways: tales of EPEC, ATEC and EHEC

2. Enteropathogenic Escherichia coli: foe or innocent bystander?