Affiliation:
1. Division of Infectious Diseases, Departments, of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
Clavulanic acid, Z-(2R,5R)-3-(β-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0] heptane-2-carboxylic acid, has been shown to be an effective inhibitor of the β-lactamases of the Richmond types II, III, IV, and V. Inhibition is a time-dependent reaction and is irreversible. Clavulanic acid had poor antibacterial activity against
Staphylococcus aureus, Enterobacteriaceae
, and
Pseudomonas aeruginosa
, with minimal inhibitory levels greater than 25 μg/ml. It did inhibit the majority of
Neisseria gonorrhoeae
at 0.1 μg/ml and
Haemophilus influenzae
at 6.3 μg/ml. Clavulanic acid acted synergistically with penicillins and cephalosporins to inhibit β-lactamase-producing
S. aureus
and
Enterobacteriaceae
. Clavulanic acid combined with ampicillin inhibited β-lactamase-producing
N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi
, and
Shigella sonnei
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
224 articles.
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