Author:
Davis C H,Putnam M D,Thwaites W M
Abstract
Previous studies, including those done with a similar species, have indicated that dihydrouracil is formed by the breakdown of uracil and is degraded into N-carbamyl-beta-alanine. (Fink et al., J. Biol. Chem. 201:349-355, 1953; S. R. Vilks and M. Y. Vitols, Mikrobiologiya 42:567-583, 1973; O. A. Milstein and M. L. Bekker, J. Bacteriol. 127:1-6, 1976). In the present work the conversion of dihydrouracil to uracil is studied in Rhodosporidium toruloides, and the growth characteristics of mutants that have lost the ability to use dihydrouracil as a source of nitrogen are examined. It is concluded that dihydrouracil must be converted to uracil before catabolism of the pyrimidine ring can take place.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference26 articles.
1. Studies on the sexuality of Rhototorula;Banno I.;J. Gen. Appl. Microbiol.,1967
2. Uracil metabolism in golden hamster after irradiation;Buric L.;Int. J. Radiat. Biol.,1977
3. Reductive degradation of pyrimidines. V. Enzymatic conversion of N-carbamyl-beta-alanine to beta-alanine, carbon dioxide, and ammonia;Campbell L. L.;J. Biol. Chem.,1960
4. Excretion of pyrimidine reduction products by the rat;Fink K.;J. Biol. Chem.,1956
5. Beta-amino acid formation by tissue slices incubated with pyrimidines;Fink R. M.;J. Biol. Chem.,1953
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献