Human Immunodeficiency Virus Type 1 Derivative with 7% Simian Immunodeficiency Virus Genetic Content Is Able To Establish Infections in Pig-Tailed Macaques-Reference-Cited by-同舟云学术

Human Immunodeficiency Virus Type 1 Derivative with 7% Simian Immunodeficiency Virus Genetic Content Is Able To Establish Infections in Pig-Tailed Macaques

Published:2007-10-15 Issue:20 Volume:81 Page:11549-11552
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Igarashi Tatsuhiko¹,Iyengar Ranjini¹,Byrum Russel A.²,Buckler-White Alicia¹,Dewar Robin L.³,Buckler Charles E.¹,Lane H. Clifford⁴,Kamada Kazuya⁵,Adachi Akio⁵,Martin Malcolm A.¹

Affiliation:

1. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

2. Bioqual, Rockville, Maryland 20850

3. Science Applications International Corporation—Frederick, Inc., Frederick, Maryland 21702

4. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

5. Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima 770-8503, Japan

Abstract

ABSTRACT A human immunodeficiency virus type 1 (HIV-1) derivative (HIV NL-DT5R ) containing sequences encoding a 7-amino-acid segment of CA and the entire vif gene from simian immunodeficiency virus (SIV) was previously shown to establish spreading infections in cultured macaque peripheral blood mononuclear cells. To assess its replicative and disease-inducing properties in vivo, HIV NL-DT5R was inoculated into pig-tailed macaques. HIV NL-DT5R generated plasma viremia in all five of the monkeys and elicited humoral responses against all of the HIV-1 structural proteins but did not cause CD4 + T-lymphocyte depletion or clinical disease. Additional adaptation will be required to optimize infectivity in vivo.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00960-07

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