pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells-Reference-Cited by-同舟云学术

pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells

Published:2022-11-23 Issue:22 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mohnke Jonas¹,Stark Irmgard¹,Fischer Mara¹,Fischer Patrick M.¹,Schlosser Andreas²,Grothey Arnhild¹,O’Hare Peter³^ORCID,Sodeik Beate⁴⁵,Erhard Florian¹,Dölken Lars¹,Hennig Thomas¹^ORCID

Affiliation:

1. Institut für Virologie und Immunbiologie, Julius-Maximilians-Universität Würzburg, Würzburg, Germany

2. Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany

3. Department of Virology, Imperial College London, Norfolk Place, London, United Kingdom

4. Institut für Virologie, Medizinische Hochschule Hannover, Hannover, Germany

5. RESIST Exzellenzcluster, Medizinische Hochschule Hannover, Hannover, Germany

Abstract

HSV-1 is a ubiquitous human pathogen that is responsible for common cold sores and may also cause life-threatening disease. pUL36 is an essential, conserved herpesvirus protein with N-terminal deubiquitinating (DUB) activity. The DUB is dispensable for HSV-1 replication in cell culture but represents an important viral immune evasin in vivo .

Funder

JMU | Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00963-22

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