Synthetic trimer and tetramer of 3-beta-D-ribose-(1-1)-D-ribitol-5-phosphate conjugated to protein induce antibody responses to Haemophilus influenzae type b capsular polysaccharide in mice and monkeys-Reference-Cited by-同舟云学术

Synthetic trimer and tetramer of 3-beta-D-ribose-(1-1)-D-ribitol-5-phosphate conjugated to protein induce antibody responses to Haemophilus influenzae type b capsular polysaccharide in mice and monkeys

Published:1992-05 Issue:5 Volume:60 Page:1826-1833
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Peeters C C¹,Evenberg D¹,Hoogerhout P¹,Käyhty H¹,Saarinen L¹,van Boeckel C A¹,van der Marel G A¹,van Boom J H¹,Poolman J T¹

Affiliation:

1. Unit for Bacterial Vaccine Development and Pathogenesis Research, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.

Abstract

Synthetic oligosaccharides derived from the capsular polysaccharide (PRP) of Haemophilus influenzae type b were conjugated to carrier proteins via a thioether linkage. Conjugates were made of trimeric and tetrameric ribose-ribitol-phosphate and tetanus toxoid or diphtheria toxin. All conjugates elicited anti-PRP antibody responses with an increasing immunoglobulin G/immunoglobulin M ratio in adult mice and monkeys. Trimer conjugates elicited lower anti-PRP antibody responses compared with tetramer conjugates. Adult monkeys responded equally well to the tetrameric oligosaccharide-tetanus toxoid conjugate as to the oligosaccharide-CRM197 conjugate (HbOC), which elicits protective levels of serum antibodies in human infants after two or three injections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.60.5.1826-1833.1992

Reference33 articles.

1. Priming and induction of Haemophilus influenzae type b capsular antibodies in early infancy by Dpo 2O, an oligosaccharide-protein conjugate vaccine;Anderson P. W.;J. Pediatr.,1987

2. Vaccines consisting of periodate cleaved oligosaccharides from the capsule of Haemophilus influenzae type b coupled to a protein carrier: structural and temporal requirements for priming in the human infant;Anderson P. W.;J. Immunol.,1986

3. Effect of oligosaccharide chain length, exposed terminal group and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus influenzae type b capsular antigen uniterminally coupled to the diphtheria protein CRM197;Anderson P. W.;J. Immunol.,1989

4. Chemo-immunological studies on conjugated carbohydrate-proteins II. Immunological specificity of synthetic sugarproteins;Avery 0.;J. Exp. Med.,1929

5. Comparison of the induction of immunoglobulin M and G antibodies in mice with purified pneumococcal type 3 and meningococcal group C polysaccharides and their protein conjugates;Beuvery E. C.;Infect. Immun.,1982

Cited by 66 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Semisynthetic Glycoconjugates as Potential Vaccine Candidates Against Haemophilus influenzae Type a;Chemistry – A European Journal;2024-07-30

2. A Multidisciplinary Structural Approach to the Identification of the Haemophilus influenzae Type b Capsular Polysaccharide Protective Epitope;ACS Central Science;2024-02-22

3. Effect of trifluoroacetic acid on the antigenicity of capsular polysaccharides obtained from various Streptococcus pneumoniae serotypes;Carbohydrate Polymers;2023-11

4. Exploring the variables influencing the immune response of traditional and innovative glycoconjugate vaccines;Frontiers in Molecular Biosciences;2023-05-16

5. Impact and Control of Sugar Size in Glycoconjugate Vaccines;Molecules;2022-09-29