β-Lactamase Gene Expression in a Penicillin-Resistant Bacillus anthracis Strain-Reference-Cited by-同舟云学术

β-Lactamase Gene Expression in a Penicillin-Resistant Bacillus anthracis Strain

Published:2004-12 Issue:12 Volume:48 Page:4873-4877
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chen Yahua¹,Tenover Fred C.²,Koehler Theresa M.¹

Affiliation:

1. Department of Microbiology and Molecular Genetics, The University of Texas—Houston Health Science Center Medical School, Houston, Texas

2. Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

ABSTRACT Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.12.4873-4877.2004

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