MexCD-OprJ Multidrug Efflux System of Pseudomonas aeruginosa : Involvement in Chlorhexidine Resistance and Induction by Membrane-Damaging Agents Dependent upon the AlgU Stress Response Sigma Factor-Reference-Cited by-同舟云学术

MexCD-OprJ Multidrug Efflux System of Pseudomonas aeruginosa : Involvement in Chlorhexidine Resistance and Induction by Membrane-Damaging Agents Dependent upon the AlgU Stress Response Sigma Factor

Published:2008-12 Issue:12 Volume:52 Page:4478-4482
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fraud Sebastien¹,Campigotto Aaron J.¹,Chen Zhilin¹,Poole Keith¹

Affiliation:

1. Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6

Abstract

ABSTRACT The biocide chlorhexidine (CHX) as well as additional membrane-active agents were shown to induce expression of the mexCD-oprJ multidrug efflux operon, dependent upon the AlgU stress response sigma factor. Hyperexpression of this efflux system in nfxB mutants was also substantially AlgU dependent. CHX resistance correlated with efflux gene expression in various mutants, consistent with MexCD-OprJ being a determinant of CHX resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01072-08

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