cfr (B), cfr (C), and a New cfr -Like Gene, cfr (E), in Clostridium difficile Strains Recovered across Latin America-Reference-Cited by-同舟云学术

cfr (B), cfr (C), and a New cfr -Like Gene, cfr (E), in Clostridium difficile Strains Recovered across Latin America

Published:2019-12-20 Issue:1 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Stojković Vanja¹,Ulate María Fernanda²,Hidalgo-Villeda Fanny³,Aguilar Emmanuel⁴,Monge-Cascante Camilo²,Pizarro-Guajardo Marjorie⁵⁶,Tsai Kaitlyn¹,Tzoc Edgardo³,Camorlinga Margarita⁷,Paredes-Sabja Daniel⁵⁶,Quesada-Gómez Carlos²^ORCID,Fujimori Danica Galonić¹⁸,Rodríguez César²^ORCID

Affiliation:

1. Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA

2. CIET and Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

3. Escuela de Microbiología, Facultad de Ciencias, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras

4. Medical Bacteriology, Department of Microbiology, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City, Mexico

5. Microbiota-Host Interactions and Clostridia Research Group, Facultad Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile

6. Millennium Nucleus in the Biology of Intestinal Microbiota, Santiago, Chile

7. Unidad de Investigación en Enfermedades Infecciosas y Parasitarias, Instituto Mexicano del Seguro Social, Mexico City, Mexico

8. Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA

Abstract

Cfr is a radical S -adenosyl- l -methionine (SAM) enzyme that confers cross-resistance to antibiotics targeting the 23S rRNA through hypermethylation of nucleotide A2503. Three cfr -like genes implicated in antibiotic resistance have been described, two of which, cfr (B) and cfr (C), have been sporadically detected in Clostridium difficile . However, the methylase activity of Cfr(C) has not been confirmed.

Funder

EULAC16/FONIS

HHS | NIH | National Institute of Allergy and Infectious Diseases

Fondo Nacional de Desarrollo Científico y Tecnológico

MINEDUC | CONICYT | Fondo de Fomento al Desarrollo Científico y Tecnológico

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01074-19

Reference39 articles.