In Vitro Activities of Voriconazole, Itraconazole, and Terbinafine Alone or in Combination against Pythium insidiosum Isolates from Brazil-Reference-Cited by-同舟云学术

In Vitro Activities of Voriconazole, Itraconazole, and Terbinafine Alone or in Combination against Pythium insidiosum Isolates from Brazil

Published:2008-02 Issue:2 Volume:52 Page:767-769
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Argenta Juliana S.¹,Santurio Janio M.²,Alves Sydney H.²,Pereira Daniela I. B.¹,Cavalheiro Ayrton S.²,Spanamberg Andréia¹,Ferreiro Laerte¹

Affiliation:

1. Programa de Pós Graduação em Ciências Veterinárias, Setor de Micologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

2. Laboratório de Pesquisas Micológicas, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

Abstract

ABSTRACT We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01075-07

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