Muropeptide Modification-Amidation of Peptidoglycan d -Glutamate Does Not Affect the Proinflammatory Activity of Staphylococcus aureus-Reference-Cited by-同舟云学术

Muropeptide Modification-Amidation of Peptidoglycan d -Glutamate Does Not Affect the Proinflammatory Activity of Staphylococcus aureus

Published:2007-04 Issue:4 Volume:75 Page:2084-2087
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kraus Dirk¹,Kalbacher Hubert²,Buschmann Julia³,Berger-Bächi Brigitte⁴,Götz Friedrich³,Peschel Andreas¹

Affiliation:

1. Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Institute, University of Tübingen, Tübingen, Germany

2. Medical and Natural Sciences Research Center, University of Tübingen, Tübingen, Germany

3. Microbial Genetics, University of Tübingen, Tübingen, Germany

4. Medical Microbiology Institute, University of Zürich, Zürich, Switzerland

Abstract

ABSTRACT Peptidoglycan muropeptides, potent proinflammatory components, are amidated in Staphylococcus aureus for unknown reasons. To study whether this modification may modulate proinflammatory capacity, cytokine induction by isogenic S. aureus strains with different amidation levels and by synthetic amidated/nonamidated muramyldipeptides was evaluated. However, amidation did not significantly affect cytokine induction. This finding contributes to defining peptidoglycan receptor specificities and indicates that further rationales for muropeptide amidation have to be considered.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01576-06

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