Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease-Reference-Cited by-同舟云学术

Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease

Published:2008-09 Issue:9 Volume:15 Page:1429-1435
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

del Rio Beatriz¹²³,Dattwyler Raymond J.¹²³,Aroso Miguel¹²³,Neves Vera¹²³,Meirelles Luciana¹²³,Seegers Jos F. M. L.¹²³,Gomes-Solecki Maria¹²³

Affiliation:

1. Department of Microbiology and Immunology, New York Medical College, Valhalla, New York

2. Biopeptides Corp., Valhalla, New York

3. Falco Biotherapeutics BV, Zernikedreef 9, 2331 CK Leiden, The Netherlands

Abstract

ABSTRACT Mucosal immunization is advantageous over other routes of antigen delivery because it can induce both mucosal and systemic immune responses. Our goal was to develop a mucosal delivery vehicle based on bacteria generally regarded as safe, such as Lactobacillus spp. In this study, we used the Lyme disease mouse model as a proof of concept. We demonstrate that an oral vaccine based on live recombinant Lactobacillus plantarum protects mice from tick-transmitted Borrelia burgdorferi infection. Our method of expressing vaccine antigens in L. plantarum induces both systemic and mucosal immunity after oral administration. This platform technology can be applied to design oral vaccine delivery vehicles against several microbial pathogens.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00169-08

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