Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates-Reference-Cited by-同舟云学术

Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates

Published:2017-08 Issue:8 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yin Dandan¹,Dong Dong²³,Li Ke⁴,Zhang Lei¹,Liang Jianliang¹,Yang Yang²,Wu Nana¹,Bao Yiyan¹,Wang Chuanqing¹,Hu Fupin²³

Affiliation:

1. Clinical Microbiology Laboratory, Department of Nosocomial Infection Control, Children's Hospital of Fudan University, Shanghai, China

2. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China

3. Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China

4. Department of Laboratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China

Abstract

ABSTRACT Five OXA-232 carbapenemase-producing Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproduced bla CTX-M-15 and bla SHV-1 genes. All isolates were resistant to ertapenem (MICs of >32 μg/ml) and meropenem (MICs of 4 to 8 μg/ml) and susceptible or intermediate to imipenem (MICs of 1 to 2 μg/ml). The bla OXA-232 gene was located on a ColE-type transformable plasmid of 6,141 bp. To the best of our knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00385-17

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