Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study-Reference-Cited by-同舟云学术

Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study

Published:2019-07 Issue:7 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Birgy André¹,Levy Corinne²³⁴,Nicolas-Chanoine Marie-Hélène⁵^ORCID,Cointe Aurélie¹,Hobson Claire A.⁵,Magnan Mélanie⁵,Bechet Stéphane²,Bidet Philippe¹,Cohen Robert²³⁴⁶,Bonacorsi Stéphane¹

Affiliation:

1. IAME, UMR 1137, INSERM, Sorbonne Paris Cité, Service de Microbiologie, Hôpital Robert Debré, AP-HP, Université Paris Diderot, Paris, France

2. Association Clinique Thérapeutique Infantile du Val de Marne (ACTIV), Saint Maur des Fossés, France

3. Groupe de Pathologie Infectieuse Pédiatrique (GPIP), Paris, France

4. Centre de Recherche Clinique du Centre Hospitalier Intercommunal de Créteil, Créteil, France

5. IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité Paris, France

6. Petits Nourrisson, Service de Néonatologie, Centre Hospitalier Intercommunal de Créteil, Unité Court Séjour, Créteil, France

Abstract

The recent emergence and diffusion in the community of Escherichia coli isolates belonging to the multidrug-resistant and CTX-M-27-producing sequence type 131 (ST131) C1-M27 cluster makes this cluster potentially as epidemic as the worldwide E. coli ST131 subclade C2 composed of multidrug-resistant isolates producing CTX-M-15. Thirty-five extended-spectrum beta-lactamase (ESBL)-producing ST131 isolates were identified in a cohort of 1,885 French children over a 5-year period.

Funder

Fondation pour la Recherche Médicale

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00382-19

Reference40 articles.

1. Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15

2. Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype

3. Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain