Performance of Commercially Available Serological Screening Tests for Human T-Cell Lymphotropic Virus Infection in Brazil

Author:

da Silva Brito Vanessa1,Santos Fred Luciano Neves2ORCID,Gonçalves Noilson Lazaro Sousa12,Araujo Thessika Hialla Almeida1,Nascimento Davi Silva Vale1,Pereira Felicidade Mota3,Boa-Sorte Ney Cristian Amaral1,Grassi Maria Fernanda Rios12,Caterino-de-Araujo Adele4,Galvão-Castro Bernardo12

Affiliation:

1. Integrated and Multidisciplinary HTLV Center, Bahiana School of Medicine and Public Health (EBMSP), Salvador, Bahia, Brazil

2. Advanced Laboratory of Public Health, Gonçalo Moniz Institute (IGM), FIOCRUZ-BA, Salvador, Bahia, Brazil

3. Gonçalo Moniz Public Health Central Laboratory (LACEN-BA), Bahia State Department of Health, Bahia, Brazil

4. Adolfo Lutz Institute, São Paulo, São Paulo, Brazil

Abstract

Serological screening for human T-cell lymphotropic virus type 1 (HTLV-1) is usually performed using enzyme-linked immunosorbent assay (ELISA), particle agglutination, or chemiluminescence assay kits. Due to an antigen matrix improvement entailing the use of new HTLV antigens and changes in the format of HTLV screening tests, as well as newly introduced chemiluminescence assays (CLIAs), a systematic evaluation of the accuracy of currently available commercial tests is warranted.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado da Bahia

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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