Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107 + CD8 + T Cells That Infiltrate the Corneas and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge

Author:

Khan Arif A.1,Srivastava Ruchi1,Vahed Hawa1,Roy Soumyabrata1,Walia Sager S.1,Kim Grace J.1,Fouladi Mona A.1,Yamada Taikun1,Ly Vincent T.1,Lam Cynthia1,Lou Anthony1,Nguyen Vivianna1,Boldbaatar Undariya1,Geertsema Roger2,Fraser Nigel W.1,BenMohamed Lbachir134

Affiliation:

1. Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California, Irvine, Irvine, California, USA

2. University Laboratory Animal Resources, University of California, Irvine, Irvine, California, USA

3. Department of Molecular Biology & Biochemistry, School of Medicine, University of California, Irvine, Irvine, California, USA

4. Institute for Immunology, School of Medicine, University of California, Irvine, Irvine, California, USA

Abstract

There is an urgent need for a vaccine against widespread herpes simplex virus infections. The present study demonstrates that immunization of HLA transgenic rabbits with a peptide/CXCL10 prime/pull vaccine triggered mobilization of HSV-specific CD8 + T cells locally into the cornea and TG, the sites of acute and latent herpesvirus infections, respectively. Mobilization of antiviral CD8 + T cells into the cornea and TG of rabbits that received the prime/pull vaccine was associated with protection against ocular herpesvirus infection and disease following an ocular HSV-1 challenge. These results highlight the importance of the prime/pull vaccine strategy to bolster the number and function of protective CD8 + T cells within infected tissues.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Eye Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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