Convergent HIV-1 Evolution upon Targeted Destabilization of the gp120-gp41 Interface-Reference-Cited by-同舟云学术

Convergent HIV-1 Evolution upon Targeted Destabilization of the gp120-gp41 Interface

Published:2021-11-23 Issue:24 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Torrents de la Peña Alba¹²,del Moral Sánchez Iván¹,Burger Judith A.¹,Bontjer Ilja¹,Isik Gözde¹,Eggink Dirk¹,van Gils Marit J.¹^ORCID,Sanders Rogier W.¹³^ORCID

Affiliation:

1. Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

2. Department of Integrative Structure and Computational Biology, The Scripps Research Institute, La Jolla, California, USA

3. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

Abstract

A successful HIV-1 vaccine most likely requires an envelope glycoprotein (Env) component, as Env is the only viral protein on the surface of the virus and the target for neutralizing antibodies. However, HIV Env is metastable and flexible because of the weak interactions between the Env subunits, complicating the generation of recombinant mimics of native Env.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00532-21

Reference83 articles.

1. HIV Entry and Its Inhibition

2. HIV-1 Membrane Fusion

3. B-cell responses to HIV infection

4. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates

5. A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure