Aquaporin Expression and Freeze Tolerance in Candida albicans

Author:

Tanghe An1,Carbrey Jennifer M.2,Agre Peter2,Thevelein Johan M.1,Van Dijck Patrick1

Affiliation:

1. Laboratorium voor Moleculaire Celbiologie and Vlaams Interuniversitair Instituut voor Biotechnologie, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium

2. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-21185

Abstract

ABSTRACT Aquaporins are members of the major intrinsic protein superfamily of integral membrane proteins which enable the transport of water, glycerol, and other solutes across membranes in various organisms. In microorganisms, the physiological role of aquaporins is not yet defined. We found a clear correlation between expression of the Candida albicans aquaporin-encoding gene AQY1 and freeze tolerance. A connection with the function for the aquaporin in the natural environment of C. albicans is, however, not obvious.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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