Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials-Reference-Cited by-同舟云学术

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

Published:2019-12-20 Issue:1 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ceballos Sara¹,Kim Choon²,Qian Yuanyuan²,Mobashery Shahriar²,Chang Mayland²,Torres Carmen¹^ORCID

Affiliation:

1. Area of Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain

2. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA

Abstract

The in vitro activities of five quinazolinone antibacterials, compounds Q1 to Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC 50 /MIC 90 values (in μg/ml) were as follows: Q1, 0.5/2; Q2, 1/4; Q3, 2/4; Q4, 0.06/0.25; and Q5, 0.125/0.5.

Funder

HHS | National Institutes of Health

MEC | Agencia Estatal de Investigación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01344-19

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