Immunization with Alpha-Toxin Toxoid Protects the Cornea against Tissue Damage during Experimental Staphylococcus aureus Keratitis-Reference-Cited by-同舟云学术

Immunization with Alpha-Toxin Toxoid Protects the Cornea against Tissue Damage during Experimental Staphylococcus aureus Keratitis

Published:2000-10 Issue:10 Volume:68 Page:6052-6055
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hume Emma B. H.¹,Dajcs Joseph J.¹,Moreau Judy M.¹,O'Callaghan Richard J.¹²

Affiliation:

1. Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center,1 and the

2. Department of Ophthalmology, Louisiana State University Eye Center,2 New Orleans, Louisiana

Abstract

ABSTRACT Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.10.6052-6055.2000

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