Heterogeneity of Latency Establishment in the Different Human CD4 <sup>+</sup> T Cell Subsets Stimulated with IL-15-Reference-Cited by-同舟云学术

Heterogeneity of Latency Establishment in the Different Human CD4 ⁺ T Cell Subsets Stimulated with IL-15

Published:2022-05-25 Issue:10 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Butta Giacomo M.¹²,Bozzi Giorgio³,Gallo Greta¹,Copaloni Gaia¹,Cordiglieri Chiara¹,Crosti Mariacristina¹,Mancino Marilena¹,Prati Daniele⁴,Simon Viviana⁵⁶⁷,Gori Andrea³⁸,Bandera Alessandra³⁸^ORCID,De Francesco Raffaele¹²,Manganaro Lara²³^ORCID

Affiliation:

1. INGM-Istituto Nazionale di Genetica Molecolare, Virology, Milan, Italy

2. Università degli Studi di Milano, Department of Pharmacological and Biomolecular Sciences, Milan, Italy

3. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Department of Internal Medicine, Milan, Italy

4. Department of Transfusion Medicine and Hematology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy

5. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

6. Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

7. Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

8. Università Degli Studi di Milano, Department of Pathophysiology and Transplantation, Centre for Multidisciplinary Research in Health Science, (MACH), Milan, Italy

Abstract

The formation of a latent reservoir is the main barrier to HIV cure. Here, we investigated how HIV latency is established in different CD4 + T cell subsets in the presence of IL-15, a cytokine that has been shown to efficiently induce latency reversal.

Funder

Italian Ministry of Health, Ricerca Finalizzata

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00379-22

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