Molecular Dissection of the Vaccinia Virus I7L Core Protein Proteinase-Reference-Cited by-同舟云学术

Molecular Dissection of the Vaccinia Virus I7L Core Protein Proteinase

Published:2003-10-15 Issue:20 Volume:77 Page:11279-11283
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Byrd Chelsea M.¹,Bolken Tove' C.²,Hruby Dennis E.³²

Affiliation:

1. Molecular and Cellular Biology Program

2. SIGA Technologies, Inc., Corvallis, Oregon 97333

3. Department of Microbiology, Oregon State University, Corvallis, Oregon 97331

Abstract

ABSTRACT The vaccinia virus I7L gene product is predicted to be a cysteine proteinase and is demonstrated in this study to be responsible for cleavage of each of the three major core protein precursors (P4a, P4b, and P25K) in vivo. Mutagenesis of the putative catalytic triad of I7L or of the cleavage sites in the core protein precursors inhibits processing. A truncated protein lost the ability to cleave the core protein precursors.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.20.11279-11283.2003

Reference16 articles.

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