DetailedAnalysis of the CD8 + T-Cell Response followingAdenovirusVaccination-Reference-Cited by-同舟云学术

DetailedAnalysis of the CD8 + T-Cell Response followingAdenovirusVaccination

Published:2003-12-15 Issue:24 Volume:77 Page:13407-13411
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yang Teng Chih¹,Dayball Kelley¹,Wan Yong Hong¹,Bramson Jonathan¹

Affiliation:

1. Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada

Abstract

ABSTRACT We examined CD8 + T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8 + T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8 + T-cell response.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.24.13407-13411.2003

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