Characterizationof Murine Leukemia Virus Restriction inMammals-Reference-Cited by-同舟云学术

Characterizationof Murine Leukemia Virus Restriction inMammals

Published:2003-12-15 Issue:24 Volume:77 Page:13403-13406
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Besnier Caroline¹,Ylinen Laura¹,Strange Benjamin¹,Lister Adrian²,Takeuchi Yasuhiro¹,Goff Stephen P.³,Towers Greg J.¹³

Affiliation:

1. Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF

2. Department of Biology, University College London, London WC1E 6BT, United Kingdom

3. Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032

Abstract

ABSTRACT Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.24.13403-13406.2003

Reference23 articles.

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4. Bieniasz, P. D. 2003. Restriction factors: a defense against retroviral infection. Trends Microbiol.11:286-291.

5. Use of a Transient Assay for Studying the Genetic Determinants of Fv1 Restriction

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