A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

O’Hara Joanne M.¹²,Wakabayashi Shoko³,Siddiqi Noman³,Cheung Elaine³⁴,Babunovic Gregory H.³⁴,Thompson Claudette M.¹,Lu Ying-Jie¹²,Rubin Eric J.³^ORCID,Malley Richard¹²^ORCID,Zhang Fan¹²

Affiliation:

1. Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Harvard Medical School, Boston, Massachusetts, USA

3. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

4. Program in the Biological and Biomedical Sciences, Harvard University, Boston, Massachusetts, USA

Abstract

Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. Here, we evaluate a novel vaccine which induces a broad immune response to Mycobacterium tuberculosis including robust antibody responses and long-lived systemic and tissue-resident memory Th1, Th17, and cytotoxic CD4 + and CD8 + T cells.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03611-22

Reference51 articles.

1. World Health Organization. 2020. Global tuberculosis report. World Health Organization, Geneva, Switzerland.

2. Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

3. Smith KC, Orme IM, Starke JR. 2012. Tuberculosis vaccines, p 789–811. In Plotkin SA, Orenstein WA, Offit PA (ed), Vaccines, 6th ed. WB Saunders, London, United Kingdom.

4. Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis

5. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

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