Of Murines and Humans: Modeling Persistent Powassan Disease in C57BL/6 Mice-Reference-Cited by-同舟云学术

Of Murines and Humans: Modeling Persistent Powassan Disease in C57BL/6 Mice

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Scroggs Stacey L. P.¹²,Offerdahl Danielle K.¹,Stewart Philip E.¹,Shaia Carl³,Griffin Amanda J.⁴,Bloom Marshall E.¹

Affiliation:

1. Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

2. Arthropod-Borne Animal Disease Research Unit, Center for Grain and Animal Health Research, Agricultural Research Service, United States Department of Agriculture, Manhattan, Kansas, USA

3. Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

4. Office of the Chief, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Abstract

Half of Powassan infection survivors experience long-term, mild to severe neurological symptoms. The progression from acute to chronic Powassan disease is not well understood, severely limiting treatment and prevention options.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03606-22

Reference60 articles.

1. Update on Powassan Virus: Emergence of a North American Tick-Borne Flavivirus

2. Phylogeny of North American Powassan virus

3. Powassan Virus: An Emerging Arbovirus of Public Health Concern in North America

4. Tick-Borne Flaviviruses, with a Focus on Powassan Virus

5. CDC. 2022. Powassan virus. https://www.cdc.gov/powassan/statistics.html.

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1. Age-dependent Powassan virus lethality is linked to glial cell activation and divergent neuroinflammatory cytokine responses in a murine model;Journal of Virology;2024-08-20

2. Age-dependent Powassan Virus Lethality is Directed by Glial Cell Activation and Divergent Neuroinflammatory Cytokine Responses in a Murine Model;2023-12-19

3. Neuroinvasive Flavivirus Pathogenesis Is Restricted by Host Genetic Factors in Collaborative Cross Mice, Independently of Oas1b;Journal of Virology;2023-07-27

4. Powassan virus persistence after acute infection;mBio;2023-06-20