Interleukin-17 Weakens the NAFLD/NASH Process by Facilitating Intestinal Barrier Restoration Depending on the Gut Microbiota-Reference-Cited by-同舟云学术

Interleukin-17 Weakens the NAFLD/NASH Process by Facilitating Intestinal Barrier Restoration Depending on the Gut Microbiota

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

He Shuying¹,Cui Shudan²,Song Wen³,Jiang Yonghong¹,Chen Hongsheng⁴,Liao Dongjiang⁴,Lu Xinpeng⁴,Li Jun⁵,Chen Xueqing¹,Peng Liang¹^ORCID

Affiliation:

1. Department of Gastroenterology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China

2. Shenzhen People's Hospital, Shenzhen, China

3. Southern Medical University, Guangzhou, China

4. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China

5. Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China

Abstract

The morbidity of NASH has increased, with limited effective treatment options. IL-17 plays a protective role in the gut mucosa in high-fat-diet (HFD)-related metabolic disorders, and HFD-related microbiota dysbiosis is responsible for a decreased number of T helper 17 (T H 17) cells in the lamina propria.

Funder

National Science Fundation of Guangdong

Fundamental Research Funds for Initial Funding

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03688-21

Reference44 articles.