Affiliation:
1. Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China
Abstract
As one of the most common foodborne transmitted zoonotic pathogens,
S.
Typhimurium infection causes diarrheal disease in humans and animals.
S.
Typhimurium infection has been implicated as an inducer for the type I interferon (IFN) response in macrophages, but the mechanisms are not fully understood. In this study, we reported that in addition to TLR4-dependent response, the cytosolic surveillance pathway (CSP) cGAS-STING is also required for the activation of type I IFN response during
S.
Typhimurium infection.
Funder
China Postdoctoral Science Foundation
National Natural Science Foundation of China
Open Project Program of the State Key Laboratory of Pathogen and Biosecurity
Starting Research Fund from the Northwest A&F University
Shaanxi Postdoctoral Science Foundation
Natural Science Basis Research Plan in Shaanxi Province of China
Publisher
American Society for Microbiology
Cited by
15 articles.
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