Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction-Reference-Cited by-同舟云学术

Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wallace Miranda J.¹²^ORCID,Jean Sophonie³^ORCID,Wallace Meghan A.¹,Burnham Carey-Ann D.¹⁴⁵⁶^ORCID,Dantas Gautam¹²⁶⁷^ORCID

Affiliation:

1. Department of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA

2. The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA

3. Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, The Ohio State University Wexner Medical Center, Columbus, OH, USA

4. Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

5. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA

6. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA

7. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA

Abstract

Anaerobic infections present unique challenges in terms of detecting and identifying the etiologic agent and selecting the optimal antimicrobial therapy. Antimicrobial resistance is increasing in anaerobic pathogens, and it is critical to understand the prevalence and mechanisms of resistance to commonly prescribed antimicrobial therapies.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | Agency for Healthcare Research and Quality

DOD | US Army | Medical Command | Congressionally Directed Medical Research Programs

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03603-21

Reference38 articles.