Immunoglobulin GM and KM Allotypes and Prevalence of Anti-LKM1 Autoantibodies in Patients with Hepatitis C Virus Infection-Reference-Cited by-同舟云学术

Immunoglobulin GM and KM Allotypes and Prevalence of Anti-LKM1 Autoantibodies in Patients with Hepatitis C Virus Infection

Published:2006-05-15 Issue:10 Volume:80 Page:5097-5099
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Muratori Paolo¹,Sutherland Susan E.²,Muratori Luigi¹,Granito Alessandro¹,Guidi Marcello¹,Pappas Georges¹,Lenzi Marco¹,Bianchi Francesco B.¹,Pandey Janardan P.³

Affiliation:

1. Department of Internal Medicine, Cardioangiology, and Hepatology, Alma Mater Studiorum-University of Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, Italy

2. Research Institute, Mission Hospitals, Inc., Asheville, North Carolina

3. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina

Abstract

ABSTRACT GM and KM allotypes—genetic markers of immunoglobulin (Ig) γ and κ chains, respectively—are associated with humoral immunity to several infection- and autoimmunity-related epitopes. We hypothesized that GM and KM allotypes contribute to the generation of autoantibodies to liver/kidney microsomal antigen 1 (LKM1) in hepatitis C virus (HCV)-infected persons. To test this hypothesis, we characterized 129 persons with persistent HCV infection for several GM and KM markers and for anti-LKM1 antibodies. The heterozygous GM 1,3,17 23 5,13,21 phenotype was significantly associated with the prevalence of anti-LKM1 antibodies (odds ratio, 5.13; P = 0.002), suggesting its involvement in this autoimmune phenomenon in HCV infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.10.5097-5099.2006

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