The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of Brucella abortus in BALB/c Mice-Reference-Cited by-同舟云学术

The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of Brucella abortus in BALB/c Mice

Published:1999-05 Issue:5 Volume:67 Page:2615-2618
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bellaire Bryan H.¹,Elzer Philip H.²,Baldwin Cynthia L.³,Roop R. Martin¹

Affiliation:

1. Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport, Louisiana 71130-39321;

2. Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge, Louisiana 708032;

3. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 010033

Abstract

ABSTRACT 2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella , and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant ( ΔentC ) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.5.2615-2618.1999

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