Mechanisms of Internalization of Staphylococcus aureus by Cultured Human Osteoblasts-Reference-Cited by-同舟云学术

Mechanisms of Internalization of Staphylococcus aureus by Cultured Human Osteoblasts

Published:1999-05 Issue:5 Volume:67 Page:2677-2681
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jevon Marc¹,Guo Chuanbin¹,Ma Beechai¹,Mordan Nicky²,Nair Sean P.¹,Harris Malcolm¹,Henderson Brian¹,Bentley George³,Meghji Sajeda¹

Affiliation:

1. Maxillofacial Surgery Research Unit1 and

2. Electron Microscopy Unit,2 Eastman Dental Institute, University College London, London, and

3. Institute of Orthopaedics, Royal National Orthopaedic Hospital Trust, Stanmore, Middlesex,3 United Kingdom

Abstract

ABSTRACT Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-mediated pathway, requiring the participation of cytoskeletal elements, principally actin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.5.2677-2681.1999

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