Inactivating and Mutagenic Effects of 1-Methyl-3-Nitro-1-Nitrosoguanidine on Intracellular Bacteriophage

Author:

Zampieri Antonio1,Greenberg Joseph1,Warren Guylyn1

Affiliation:

1. Palo Alto Medical Research Foundation, Palo Alto, California 94301

Abstract

1-Methyl-3-nitro-1-nitrosoguanidine (NG) was able to inactivate and mutate adsorbed but not free coliphage T2. Coliphage T4 was as sensitive to NG as T2. When treatment was delayed for 5 min or longer after adsorption of T2, the phage became increasingly refractory to NG inactivation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference14 articles.

1. Adams M. H. 1959. Bacteriophages. Interscience Publishers Inc. New York.

2. Optimal conditions for mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli K12;Adelberg E. A.;Biochem. Biophys. Res. Commun.,1965

3. Prophage induction by N-methyl-N'-nitro-N-nitrosoguanidine;Allan R. K.;Can. J. Microbiol.,1966

4. Effects of nitrous acid on intracellular T2 bacteriophage;Baylor M. B.;Virology,1962

5. Resistance to ultraviolet light as an index to the reproduction of bacteriophage;Benzer S.;J. Bacteriol.,1952

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1. Genetic effects of N-methyl-N′-nitro-N-nitrosoguanidine and its homologs;Mutation Research/Reviews in Genetic Toxicology;1982-09

2. Induction of 6-thioguanine resistance in synchronized human fibroblast cells treated with methyl methanesulfonate, N-acetoxy-2-acetylaminofluorene and N-ethyl-N′-nitro-N-nitrosoguanidine;Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;1981-09

3. Mutagenic specificity of nitrosomethylurea in bacteriophage T4;Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;1981-08

4. Deoxyribonucleic acid repair in bacteriophage;Microbiological Reviews;1981-03

5. DEOXYRIBONUCLEIC-ACID REPAIR IN BACTERIOPHAGE;MICROBIOL REV;1981

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